Exercise Can Help Keep Cancer At Bay

Written by

Liz Szabo

USA Today

From www.coloradoan.com

Exercise has given Lu-Ann Doria more energy, confidence and strength. It may also help her stay cancer-free, doctors say.

Doria, 57, began working out for the first time three years ago, after recovering from breast cancer therapy. At first, she was so fatigued she had to nap before dance class.

Now, Doria is exercising five days a week. She has tried step aerobics, a dance class called Zumba, even weightlifting.

"I feel like I can do things; before, I was talking myself out of things," said Doria, of Rye, N.Y., who works with a personal trainer at the YMCA through a joint program with Livestrong for cancer survivors.

And, even with rheumatoid arthritis, Doria said, "I sleep better. I don't feel stressed. Two weeks ago, I went to my rheumatologist, and she lowered my medication. She said, 'I don't feel any inflammation in your body. Keep doing what you're doing."'

Researchers have known for years that people who are active and trim are less likely to develop cancer. And survivors who exercise and keep a healthy weight are less likely to relapse.

Only recently, however, have scientists begun to untangle how staying active helps keep cancer at bay.

While exercise may not change the inner workings of a tumor cell, physical activity may change the cell's neighborhood - the surrounding tissue, blood vessels and immune cells - known as the "microenvironment," said Patricia Ganz, a breast cancer specialist at UCLA's Jonsson Comprehensive Cancer Center.

"It's a new frontier for cancer research," said Pamela Goodwin, professor of medicine at Mount Sinai Hospital, University of Toronto.

Healthy neighborhoods are as important to cells as they are to children, said William Li, president of the Boston-based Angiogenesis Foundation, which funds research in cancer and other diseases.

He compares a lone tumor cell to a "bad kid" living in a good neighborhood. Even an aspiring juvenile delinquent won't be able to cause much trouble if he's surrounded by watchful parents, neighbors and local police. Exercise helps improve the neighborhood, keeping cancers in check, Li said. Failing to exercise - and putting on a lot of weight - damages the neighborhood, making it easier for cancers to wreak havoc.

In particular, exercise helps to prevent chronic inflammation, a process that can fuel cancers by changing the neighborhood around a tumor cell. Exercise helps lower levels of both insulin and sex hormones, such as estrogen, which release growth factors that let tumor cells survive and spread, Li said. And, as Doria has learned, exercise also helps relieve psychological stress, which may further reduce inflammation, Ganz said.

But smoking, heavy drinking, being obese and eating processed foods all increase inflammation.

Doctors still have lots to learn, of course, and they're quick to note that many unknown factors may cause cancer.

"We don't want women with breast cancer to feel like they caused their breast cancer or that they caused it to come back," Goodwin says.

Still, doctors are discovering a growing number of ways the tumor environment can stop cancers before they start, or help them spread, Ganz said. Doctors already target the tumor neighborhood with drugs such as Avastin, which cut off a cancer's blood supply. Learning more about the microenvironment might provide new tools, such as drugs that curb inflammation to prevent cancer or treat it more effectively, Ganz said.

"The microenvironment, in some cases, may make the difference between a tiny little cancer that doesn't hurt you, and one that becomes a major danger to your life," said Lynn Matrisian, a cancer biologist at the Vanderbilt University School of Medicine in Nashville.

"It's an entirely new way of thinking about cancer," Li said. "The microenvironment actually protects us from cancer in ways we don't fully understand."

Hidden cancers

Scientists believe the body may be battling hidden cancers all the time.

With 10 trillion cells in the human body, "we are all developing microscopic cancer cells continuously," Li said.

Most of the time, these cancers never grow beyond the size of a pinprick, or grow too slowly to cause trouble; people who have them live long lives and die of other causes, Li said.

Autopsy studies, for example, show that most old men have cancer cells in their prostates, and most women have malignant cells in their breasts, even if they've never been diagnosed with cancer. And by age 70, virtually everyone has cancer cells in their thyroid glands, Li said.

Interestingly, while Japanese men also develop microscopic malignancies in the prostate, they are much less likely to be diagnosed with a noticeable prostate cancer, Ganz said. That suggests something about their lifestyle, such as their diet or physical activity, may keep their tumors under wraps.

There are many ways the microenvironment could drive cancer, said researcher Robert Weinberg, of the Whitehead Institute for Biomedical Research, and a biology professor at Massachusetts Institute of Technology.

For example, insulin and a related protein, called insulinlike growth factor, can interfere with a cancer cell's efforts to commit suicide, Weinberg said. A cell's internal security system often goes on alert when cancer genes become active, ordering the cell to self-destruct.